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Hence, studies that intend to produce algorithms that are patient‐specific, identifying patient‐specific biomarkers, should avoid the University of Bonn and Hauz Khas datasets. The dataset that contains the largest number of subjects is TUSZ with 592, followed by the Helsinki University Hospital and CHB‐MIT datasets with 79 and 23 subjects, respectively. The TUSZ corpus contains the most variation in terms of EEG characteristics in the recordings. While most recordings obtained originated from human subjects, datasets from Kaggle competitions such as Kaggle UPenn and American Epilepsy Society contain EEG recordings of both human and canine subjects. We adapted the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) guidelines to perform a data search as shown in Figure 1. The search of relevant literature that used an EEG seizure dataset was divided into two parts.
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There were patients with missing data on pupil reactivity, events of hypoxia, hypotension, and hypoglycemia, and these were excluded from the comparative analysis. Data on GCS, ISS, (27), and HCTS sum are presented in medians and ranges. Differences between groups are analyzed with the Mann–Whitney U-test. The levels of the biomarkers were not normally distributed and are presented as medians with interquartile ranges (IQRs). Differences in biomarker levels between the two outcome groups were analyzed with the Mann–Whitney U-test. Aviator online casino game broke into the industry not long ago, but managed to make thousands, if not millions, of fans across the world.
However, the noncontinuous Hauz Khas dataset contains preictal, ictal, and interictal events, allowing for its use for both tasks. On the other hand, the remaining continuous datasets are more flexible, since the recordings capture preictal, ictal, and interictal events. Table 4 also shows the main application that is suitable for the use of the datasets. Admission levels of IL-10 and Aβ40 improve the prognostic performance of the HCTS in discriminating patients with unfavorable and favorable outcomes. When studied alone, HCTS had the highest pAUCs of the tested covariates, followed by Aβ40 and Aβ42. Although the individual specificities of the HCTS and biomarkers remained low (2–33%) in isolation, the optimal combination panel yielded a specificity of 59% when the sensitivity was set above 90%.
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- The other exception is the CHB‐MIT dataset with 1‐hour length except for six patients, and occasional shorter segment lengths.
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In addition, we could not use the levels of UCH-L1 from the Human Neurology 4-Plex assay in the current analyses because the coefficients of variation were at a level where the results are not reliable. We also used the National Institute for Health and Care Excellence criteria for head CT imaging, and the results might not be applicable for other head CT rules due to differences in case selection. The fairly small study cohort also increases the risk of over-fitting bias, and therefore, the results should be verified and validated in a larger cohort.
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48 , 49 Further, studies have shown that there are significant changes in the heart rate such as tachycardia and increased heart rate variability.
The only dataset that applied band filtering of between 0.5 and 70 Hz was the Hauz Khas dataset. Each of the segments in TUSZ is pruned to reduce the length of each segment to less than an hour. Noncontinuous datasets generally come with random segmentation, where there are no time relationships between each of the neighboring segments. Noncontinuous datasets that are randomly segmented, such as the University of Bonn, Hauz Khas, and Kaggle datasets, are chosen from the unpublished continuous dataset based on multiple criteria depending on the classification tasks.
- These two models also presented better calibration, demonstrated by higher Brier Score values (Table 3).
- While studies such as TUSZ included the total seizure duration, most datasets did not.
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JP has received a speaker’s fee from the Finnish Medical Association. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor is currently organizing a Research Topic with some of the authors OT and J-CS.
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, 47 ML models with natural language processing components might be able to interpret medical records of each patient to better tune the model to detect or predict patient‐specific seizures. Using EMG‐based seizure detection devices attached on specific body parts such as the arms, studies have demonstrated the ability to detect generalized tonic–clonic seizures (GTCS) to detect seizures with sensitivities of more than 90%.
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Regarding the temporal properties of EEG datasets, the length of segments varies across all datasets for both continuous and noncontinuous datasets as shown in Table 8. Within the same dataset itself, the length of each segment is different where each seizure event can be divided into multiple ictal or preictal segments. This can be seen in Table 8, where the Helsinki University Hospital EEG dataset has a median epoch length of 74 minutes, and the Neurovista ictal dataset has different seizure segment lengths, with an average of 107 seconds.
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